New strategies for the enhancement and promotion of local identity in coastal areas. The case of the Sorrento peninsula

The paper proposes to consider the port areas as strategic nodes for the valorisation of the territory. In these areas the reuse of buildings represents the opportunity to integrate new economic and cultural activities for tourist promotion and enhancement of local resources. The localisation of new cultural, recreational and promotional activities can also increase territorial competitiveness and attractiveness and employment rate, related to functional mix and economic activities. In many contemporary cities, recent rehabilitation processes carried out this strategy, including the reuse of existing buildings in the ports by new activities especially connected with the maritime tradition of the city. The proposal aims to verify the opportunity to build a strategy based on valorisation and management of excellent coastal areas characterized by a network of small ports in small cities. The Sorrento Peninsula (Italy) represents an emblematic case study in order to enhance the role of port areas for the promotion of natural, cultural and historical resources in a systemic vision of the territory. The reuse of existing buildings for tourism promotion together with the rehabilitation of the pedestrian paths system can contribute to realize a network that – starting from port areas – improves accessibility and usability

A platform to support object database research

Databases play a key role in an increasingly diverse range of applications and settings. New requirements are continually emerging and may differ substantially from one domain to another, sometimes even to the point of conflict. To address these challenges, database systems are evolving to cater for new application domains. Yet little attention has been given to the process of researching and developing database concepts in response to new requirements. We present a platform designed to support database research in terms of experimentation with different aspects of database systems ranging from the data model to the distribution architecture. Our platform is based on the notion of metamodel extension modules, inspired by proposals for adaptive and configurable database management systems. However, rather than building a tailored system from existing components, we focus on the process of designing new components. To qualitatively evaluate our platform, we present a series of case studies where our approach was used successfully to experiment with concepts designed to support a variety of novel application domains

Theoretical and Numerical Hydromechanics Analysis of Self-Pitching Propellers

The development of design-oriented modelling techniques to predict Self-Pitching Propellers (SPP) hydrodynamic and dynamic behaviour is here addressed. Two hydrodynamics approaches are described and validated against literature data. Both Controllable-Pitch Propellers (CPP) and SPP test cases are considered. In addition, a general theoretical Reduced Order Model (ROM) for blade hydrodynamics unsteady loads is proposed to investigate blade equilibrium stability. Numerical results are shown in terms of performance, spindle moment and pitch setting equilibrium conditions. The proposed Blade Element Momentum Theory (BEMT) model shows to be well suited to capture SPP performance, spindle moment and blade equilibrium condition once a devoted tailoring process of model parameters is performed

The potential etiopathogenetic role and diagnostic utility of CD3+ CD56+ regulatory T lymphocytes in Myelodysplastic Syndromes

Serio et al. show a significant reduction of CD3+CD56+ regulatory T cells (TR3-56) in bone marrow (BM) of low-risk myelodysplastic subjects, as compared with the high-risk and the AML group; in addition, the BM frequency of mature granulocytes, a recognised marker of residual effective haematopoiesis, was observed to inversely correlate with TR3-56 in the MDS cohort. Such data are of great interest and confirm and extend, in an independent MDS cohort, the trend-increase of BM TR3-56 from very low/low risk to high/very high risk MDS and the inverse correlation with the cytotoxic T-cell (CTL) activity, likely fostering the escape of leukaemic blasts to immune-surveillance, by us recently described

Zirconia-reinforced lithium silicate (ZLS) mechanical and biological properties: A literature review

Objectives: This paper aimed to provide a literature review of the mechanical and biological properties of zirconia-reinforced lithium silicate glass-ceramics (ZLS) in Computer-aided design / Computer-aided manufacturing (CAD/CAM) systems.Data/Sources: An extensive search of the literature for papers related to ZLS was made on the databases of PubMed/Medline, Scopus, Embase, Google Scholar, Dynamed, and Open Grey. The papers were selected by 3 independent calibrated reviewers.Study selection: The search strategy produced 937 records. After the removal of duplicates and the exclusion of papers that did not meet the inclusion criteria, 71 papers were included.Conclusions: After reviewing the included records, it was found that two types of ZLS (Vita Suprinity PC; Vita Zahnfabrik and Celtra Duo; Dentsply Sirona) are nowadays available on the market for CAD/CAM systems, similar in their chemical composition, microstructure, and biological-mechanical properties. ZLS is reported to be a biocompatible material, whose fracture resistance can withstand physiological chewing loads. The firing process influences the improvements of strength and fatigue failure load, with a volumetric shrinkage. To date, ZLS can be considered a viable alternative to other glass-ceramics for fixed single restorations. Clinical Significance: . As to biocompatibility and mechanical properties of ZLS, data are still scarce, often controversial and limited to short-term observational periods. These promising ceramics require further in vitro/ in vivo studies to accurately define mechanical and biological properties, mainly in the long-term performance of restorations produced with such materials

Graminex pollen: phenolic pattern, colorimetric analysis and protective effects in immortalized prostate cells (PC3) and rat prostate challenged with LPS

Prostatitis, a general term describing prostate inflammation, is a common disease that could be sustained by bacterial or non-bacterial infectious agents. The efficacy of herbal extracts with antioxidant and anti-inflammatory effects for blunting the burden of inflammation and oxidative stress, with possible improvements in clinical symptoms, is under investigation. Pollen extracts have been previously reported as promising agents in managing clinical symptoms related to prostatitis. The aim of the present work was to evaluate the protective effects of Graminex pollen (GraminexTM, Deshler, OH, USA), a commercially available product based on standardized pollen extracts, in rat prostate specimens, ex vivo. In this context, we studied the putative mechanism of action of pollen on multiple inflammatory pathways, including the reduction of prostaglandin E2 (PGE2), nuclear factor kappa-light-chain-enhancer of activated B cells (NFB), and malondialdehyde (MDA), whose activities were significantly increased by inflammatory stimuli. We characterized by means of chromatographic and colorimetric studies the composition of Graminex pollen to better correlate the activity of pollen on immortalized prostate cells (PC3), and in rat prostate specimens challenged with Escherichia coli lipopolysaccharide (LPS). We found that Graminex pollen was able to reduce radical oxygen species (ROS) production by PC3 cells and MDA, NFB mRNA, and PGE2 levels, in rat prostate specimens. According to our experimental evidence, Graminex pollen appears to be a promising natural product for the management of the inflammatory components in the prostate

Properties and limits of some essential oils: chemical characterisation, antimicrobial activity, interaction with antibiotics and cytotoxicity

Because of the emergence of multi-drug resistance bacteria and fungi, alternatives to conventional antimicrobial therapy are needed. This study aims to evaluate in vitro the antimicrobial activity of: Mirtus communis, Coriandrum sativum, Pelargonium capitatum, Cuminum cyminum, Ocimum basilicum, Citrus aurantium amara, Cymbopogon. winterianus, Cymbopogon martini, Salvia sclarea, Melaleuca alternifolia and Mentha suaveolens essential oils on bacteria and fungi, in relation to their chemical composition. The potential interaction of M. alternifolia (TTO), C. sativum (CDO) and M. suaveolens (EOMS) essential oils when used in combination with gentamicin and fluconazole has been evaluated. The results obtained showed a synergic effect on some bacteria and fungi, with FICI values ≤5. The cytotoxicity of TTO, CDO and EOMS was investigated towards HeLa cells. Only EOMS did not result cytotoxic at the active concentrations on micro-organisms. Further studies are necessary to obtain optimal ratios and dosing regimens for higher therapeutic efficacy and to decrease toxicological profiles

The Zooxanthellate Jellyfish Holobiont Cassiopea andromeda, a Source of Soluble Bioactive Compounds

Cassiopea andromeda (Forsskål, 1775), commonly found across the Indo-Pacific Ocean, the Red Sea, and now also in the warmest areas of the Mediterranean Sea, is a scyphozoan jellyfish that hosts autotrophic dinoflagellate symbionts (family Symbiodiniaceae). Besides supplying photosynthates to their host, these microalgae are known to produce bioactive compounds as long- chain unsaturated fay acids, polyphenols, and pigments, including carotenoids, with antioxidant properties and other beneficial biological activities. By the present study, a fractionation method was applied on the hydroalcoholic extract from two main body parts (oral arms and umbrella) of the jellyfish holobiont to obtain an improved biochemical characterization of the obtained fractions from the two body parts. The composition of each fraction (i.e., proteins, phenols, fay acids, and pigments) as well as the associated antioxidant activity were analyzed. The oral arms proved richer in zooxanthellae and pigments than the umbrella. The applied fractionation method was effective in separating pigments and fay acids into a lipophilic fraction from proteins and pigment–protein complexes. Therefore, the C. andromeda–dinoflagellate holobiont might be considered as a promising natural source of multiple bioactive compounds produced through mixotrophic metabolism, which are of interest for a wide range of biotechnological applications

Newsletter Serit n. 9 - Marzo 2014

La IVa Giornata Nazionale della Piattaforma Serit è stata dedicata ad esempi di “best practice” di progetti di ricerca, finanziati dal programma quadro FP7-Security Research Project, che si sono dimostrati “end-users friendly”. Il numero di questa newsletter offre una breve sintesi della giornata